The two Asian isolates JICS and Klug92G-4 red were also phylogenetically close to the north American ones greenwhereas the European isolates blue seemed to form a few clades that had distance from the one with JICS and some north American strains. On the other hand, S.
Whole genome-wide phylogenetic relationship among S. Maximum-likelihood tree based on SNPs extracted from the genomes by mapping them to reference sequence of S. The branch length indicates proportions of SNPs to the total 23, ones called among the 33 genomes refer to the scale bar.
Strains isolated in Asia, Europe and north America are indicated in red, blue and green, respectively. Strains without information about locations of isolation are indicated in gray. The complete sequencing of the genome of methicillin-resistant S. Unlike S. Similar findings, however, were observed in other S.
Dot plots have shown that coagulase-negative staphylococci had large-scale genome inversions when compared with S.
It was also notable that regions around the origins of replication of S. Because the non-homologous region was shifted to the right side of the genome map, that side could include sequences that lead to the GC-skew bias. We also found that frequently-transcribed genes that can affect replication speed, such as those encoding ribosomal RNAs, ribosomal proteins and tRNAs, located on the right side of the genome map were concentrated in JICS ST3 was found to be the most frequently isolated In contrast, Taiwan, ST6 In contrast to other S.
This hypothesis is consistent with the finding that JICS was isolated from a patient with bloodsteam infection. Moreover, the lwrC1 and lwrC2 genes were accompanied by transglycosylases and related genes. In other genera, these glycosylated proteins are secreted by specific mechanisms involving SecA2 and SecY2 that are distinct from general secretory mechanisms.
These secreted proteins subsequently attach covalently to the bacterial cell walls, increasing their affinity to platelets Investigations to identify the molecules targeted by the lwrC1 and lwrC2 gene products are ongoing.
Analysis also revealed that the lwrC1 locus has the highest homology to S. Because both S. Three genes responsible for antibiotic resistance were identified in JICS No other known S. Genetic methods are required to identify S. For example, virulence can be evaluated in a library subjected to transposon-insertion mutagenesis using a model organism This approach may provide more information needed to understand the pathogenicity of S. Because fewer people have been infected by S.
This drug-resistant S. Our analysis using whole genome sequences of S. Further analyses will elucidate relationship among carriage of SCC mec s, their structures and sequence types of other parts of chromosomes, and the information would provide us evolutional pathways of MRSL strains.
This comparative analysis of S. These findings suggested that novel types of S. Freney, J. Staphylococcus lugdunensis sp. Frank, K. From clinical microbiology to infection pathogenesis: how daring to be different works for Staphylococcus lugdunensis. Zinkernagel, A. Significance of Staphylococcus lugdunensis bacteremia: report of 28 cases and review of the literature.
Tee, W. Tibebu, M. Severe hospital acquired pneumonia and septicemia due TO methicillin resistant Staphylococcus lugdunensis in a newborn in Northwestern Ethiopia.
Ethiopian medical journal 5299— Ho, P. Carriage niches and molecular epidemiology of Staphylococcus lugdunensis and methicillin-resistant S. Spanu, T. Ventriculitis due to Staphylococcus lugdunensis : two case reports. Tan, T. Microbiological characteristics, presumptive identification, and antibiotic susceptibilities of Staphylococcus lugdunensis.
Wu, A. Clinical and microbiological characteristics of community-acquired Staphylococcus lugdunensis infections in Southern Taiwan. Tseng, S.
Genotypes and phenotypes of Staphylococcus lugdunensis isolates recovered from bacteremia. Lin, J, Permission - Radial - Axis (Cassette). Clinical experience and microbiologic characteristics of invasive Staphylococcus lugdunensis infection in a tertiary center in northern Taiwan. Yen, T.
Emergence of oxacillin-resistant Staphylococcus lugdunensis carrying staphylococcal cassette chromosome mec type V in central Taiwan.
Bhumbra, S. Mehmood, M. Staphylococcus lugdunensis gluteal abscess in a patient with end stage renal disease on hemodialysis. Ainoda, Y. Al-Charrakh, A. First record of isolation and characterization of methicillin resistant Staphylococcus lugdunensis from clinical samples in Iraq. Szabados, F. Goris, J. Richter, M. Shifting the genomic gold standard for the prokaryotic species definition. Yoon, S. A large-scale evaluation of algorithms to calculate average nucleotide identity.
Chin, C. Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data. Sommer, D. Minimus: a fast, lightweight genome assembler. Aziz, R. Larsen, M. Multilocus sequence typing of total-genome-sequenced bacteria. Joensen, K. Real-time whole-genome sequencing for routine typing, surveillance, and outbreak detection of verotoxigenic Escherichia coli. Camacho, C. Clausen, P. Rapid and precise alignment of raw reads against redundant databases with KMA. Kaas, R.
Solving the problem of comparing whole bacterial genomes across different sequencing platforms. Felsenstein, J. Evolutionary trees from DNA sequences: a maximum likelihood approach. Tse, H. Interestingly, in my quest to research bearings, I learned the only quality standard associated with bearings is far from robust. What the ABEC standard qualifies is bore diameter an acceptable variation of the size of the inner bearing holeparallelism width variationand the radial raceway run-out variations in the groove in which the balls sit.
The folks at Enduro Bearings argue that, for bicycles, the materials are far more important than ABEC ratings and that for most applications, ABEC 3 and 5 are appropriate for all things bicycle. As for the 7 and 9 ratings, that level of precision is for equipment that sees rotations in the thousands or hundreds of thousands per minute — a tad overkill for cycling!
Two rubber seals — sound technical? Seals are kind of a dry and boring topic pun intended — bearing humor. They have capillary-like action, with regards to cleaning agents and water, and thus their design is critical. There are three major considerations regarding seals — frictionprotection and serviceability. Friction is a major point of contention for cartridge bearings, and while less is better, a little friction can be an indication of protection.
The job of the seal is just that, to keep grease in and contaminants out. But once you have contamination, can you clean and service your cartridge without damaging the seal? Chromium steelC stainless steelXD15 super nitrogen stainlessand silicone nitride ceramic are all available, and then some.
Maintenance should include the following tools: bearing removal toolsbearing installation toolsa small flat-bladed pick and a dental pick with a sharp curved edge.
Proper installation may seem simple enough, but misalignment from improper installs are a big cause of premature wear. Black seals are meant to face the centerline, while red should face outwards. Proper bearing maintenance ends with proper lubrication, which could be anything from sticky waterproof grease to thin frictionless lube.
Depending on the application, the type of bearing system used, how often maintenance is done, and the type of environmental exposure the system experiences, dictate the best lubricant.
Press fit gained in popularity because of Permission - Radial - Axis (Cassette) cross-threading issues at factories. True story. When the assemblers would cross-thread a bottom bracket in a frame during installation it Permission - Radial - Axis (Cassette) the frame, increasing rejection rates and costing manufacturers money. Frustrating for them, and so press-fit was born… frustrating for us. That frustration now ends up on our plates and the creaking, play and backing out of cups that stems from poor tolerances have proven an issue for a lot of riders.
Assessment of left ventricular myocardial deformation by cardiac MRI strain imaging reveals myocardial dysfunction in patients with primary cardiac tumors.
Cao, Y. Increased myocardial extracellular volume assessed by cardiovascular magnetic resonance T1 mapping and its determinants in type 2 diabetes mellitus patients with normal myocardial systolic strain. American Diabetes Association. Standards of medical care in diabetes— Diabetes Care 36 Suppl 1S11—S66 Amaki, M. Diagnostic concordance of echocardiography and cardiac magnetic resonance-based tissue tracking for differentiating constrictive pericarditis from.
Ortega, M. Relation of left ventricular dyssynchrony measured by cardiac magnetic resonance tissue tracking in repaired tetralogy of Fallot to ventricular tachycardia and death.
Bahtiyar, G. Heart failure: a major cardiovascular complication of diabetes mellitus. Diabetes Rep. Wilmot, E. Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction.
Diabetes Med. Wierzbowska-drabik, K. Diabetes as an independent predictor of left ventricular longitudinal strain reduction at rest and during dobutamine stress test in patients with significant coronary artery disease.
Liu, X. Habek, J. Left ventricular diastolic function in diabetes mellitus type Permission - Radial - Axis (Cassette) patients: correlation with heart rate and its variability.
Acta Diabetol. Nakai, H. Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration. Wang, J. Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure.
Edwards, N. Subclinical abnormalities of left ventricular myocardial deformation in early-stage chronic kidney disease: the precursor of uremic cardiomyopathy?. Jurcut, R. Strain rate imaging detects early cardiac effects of pegylated liposomal doxorubicin as adjuvant therapy in elderly patients with breast cancer. Buckberg, G. Cardiac mechanics revisited: the relationship of cardiac architecture to ventricular function.
Circulation 9— Oxborough, D. Interpretation of two-dimensional and tissue Doppler-derived strain epsilon and strain rate data: is there a need to normalize for individual variability in left ventricular morphology?. Stanton, T. Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring.
Li, R. Myocardial deformation in cardiac amyloid light-chain amyloidosis: assessed with 3T cardiovascular magnetic resonance feature tracking.
Diagnostic concordance of echocardiography and cardiac magnetic resonance-based tissue tracking for differentiating constrictive pericarditis from restrictive cardiomyopathy. Download references. Study concepts: L. Study design: L. Data acquisition: M.
Quality control of data and algorithms: Y. Data analysis and interpretation: L. Statistical analysis: L. Manuscript preparation: L. Manuscript editing: L. Manuscript review: Y. Correspondence to Zhi-gang Yang or Ying-kun Guo.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions. Xie, L. Assessment of left ventricular deformation in patients with type 2 diabetes mellitus by cardiac magnetic resonance tissue tracking. Sci Rep 10, Download citation.
Received : 11 November Accepted : 22 July Published : 04 August By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content. Subjects Diabetes complications Magnetic resonance imaging. Abstract To quantify the global and regional left ventricular LV myocardial strain in type 2 diabetes mellitus T2DM patients using cardiac magnetic resonance CMR tissue-tracking techniques and to determine the ability of myocardial strain parameters to assessment the LV deformation.
Download PDF. Introduction Type 2 diabetes mellitus T2DM is a metabolic disease associated with high morbidity. Basic information and laboratory data collection For all T2DM patients, we recorded age, sex, disease duration, blood pressure, height, and weight; we then calculated BMI. Figure 1. Full size image. Full size table. Figure 2. Figure 3. Figure 4. Figure 5. Discussion Diabetic cardiomyopathy is one of the most common cardiovascular complications, yet no standardized guidelines exist to make the diagnosis and consequently potential cardiovascular complications are often overlooked in the early stages of T2DM.
Limitations The present study has some limitations. Conclusion The assessment of strain parameters obtained via CMR tissue tracking, allows for the evaluation of early cardiac deformation in T2DM patients. Permission - Radial - Axis (Cassette) 1. View author publications. Ethics declarations Competing interests The authors declare no competing interests.
Additional information Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary information. Supplementary Information.
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